In the second season of House, the main story arc is one that focuses on the relationship between House and his previous flame, Stacy. House treated her husband Mark in the season prior (he is paralyzed as a result, against House’s best efforts to stop it from happening), and the two reconnected. Their relationship is quite a mess, as both have feelings for the other but refuse to acknowledge the pachyderm in the room. They finally kiss in the episode “Failure to Communicate”, and have resolved (without actually saying it to each other at first because, god forbid, they be wrong about the other person’s feelings) to try again. Stacy decides to leave Mark for House, but he, House, panics, telling her that House cannot make her happy, and that she should stay with Mark, in the episode “Need to Know”. She leaves, and Wilson is furious at Houses need to be self destructive and self loathing. House is affected by this for, I think, the entirety of the series, up to when he and Cuddy get together at the end of the sixth season.
