House, Season 4

House, Season 4 really changes the tone of the show. Before, it was much more House centric, but with the departure of Cameron, Chase and Foreman, it begins to focus more on the people around House. Well, after the first few episodes, anyways. House is left without a team (obviously) and refuses to hire a new one. House says its because he can do just fine without a team, though its implied that the emotional backlash of being wholly rejected as a person hurt his feelings a bit, to say the least.
-Spoilers for Season 4 of House after the break!-

House, Season 2

Continuing on with the theme of my previous post, we come to the second season of the television show, House. --Be advised that this post contains spoilers from the second and sixth seasons of House--

In the second season of House, the main story arc is one that focuses on the relationship between House and his previous flame, Stacy. House treated her husband Mark in the season prior (he is paralyzed as a result, against House’s best efforts to stop it from happening), and the two reconnected. Their relationship is quite a mess, as both have feelings for the other but refuse to acknowledge the pachyderm in the room. They finally kiss in the episode “Failure to Communicate”, and have resolved (without actually saying it to each other at first because, god forbid, they be wrong about the other person’s feelings) to try again. Stacy decides to leave Mark for House, but he, House, panics, telling her that House cannot make her happy, and that she should stay with Mark, in the episode “Need to Know”. She leaves, and Wilson is furious at Houses need to be self destructive and self loathing. House is affected by this for, I think, the entirety of the series, up to when he and Cuddy get together at the end of the sixth season.